As others have stated, it’s because some meds stimulate acid production and can damage your stomach/intestines.
Anecdote: I was prescribed Diclofenac for pain management, back when I was working a job where I couldn’t risk getting/being high while on shift.
The doc was a really down-to-earth type, so when he was going over the side effects and warnings, he had a *very memorable* way to emphasize that you have to take it with food:
“You cannot take Diclofenac on an empty stomach. If you take this without food in your stomach, it will mess you up. ***You will shit blood for several days***. I don’t want to get a call from you in a week saying ‘doc, there’s something wrong! I’m shittin blood!’ It’ll be because you forgot to eat before taking your meds.”
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