You are asking “why does a chemical effect on cognition impact people with abnormal cognition different than it does normal people?”
The question kind of answers itself. If your brain chemistry is different, you react to brain altering chemicals differently as a direct result.
It would be like a diabetic asking why non-diabetic people don’t need insulin shots after eating a candy bar.
Many stimulant type drugs have the opposite effect in ADHD brains. The primary medications for ADHD are stimulants, which is why you would hear cases of false diagnosis to fuel drug rings, or kids in school selling their prescriptions to make some cash flow (often you hear about it after someone ODs).
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