Why does it seem cis men on TRT need a higher dose than trans men on HRT?

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Whenever I see trans men talk about their dose and levels, the average dose seems to be 60-100mg ~~of~~ weekly to get to 500-1000ng/dL. But when I see cis men (with low testosterone) talking about it, their average dose seems to be 100-200mg weekly to get to 500-1000ng/dL. What’s the difference?

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Anonymous 0 Comments

highly dependent on a number of factors, but there is an enzyme Aromatase that converts testosterone to estrogen, which is found in higher levels in biological women. I would assume depending on the transition, the dosage is higher to account and overcome the conversion that would come with that enzyme being more prevalent.

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