Across the body there are specific receptors that send a message to the brain when they encounter heat. Alcohol lowers the temperature at which they fire the signal, so that’s why you have a ‘burning’ sensation when put antiseptic (containing alcohol) on an open wound, and why you can get a similar sensation if you drink neat alcoholic spirts. Search for “ethanol VR1 receptor” if you want more in depth info.
Nothing to do with cells dying as is being suggested by others.
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