Not a biologist or an often lsd user but I read somewhere it all depends on your mental state there is a chemical (might be serotonin not sure) in lsd and that will boost what ever mood you are in if you’re super happy you’ll have a really good and fun high but on the other spectrum of you’re super sad you’ll have a really bad and sad high. Hopefully this explains it. I could be wrong I read the article a while back
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