Not a biologist by any means, but my understanding is the when we form relationships, and particularly romantic relationships, our brains create physical bonds associated with that person (or animal). When loss happens, there is a physical breaking of those bonds in our brain signaling that something is wrong and sets off pain signals. However, because our brain can’t pinpoint what part of the body is injured, it tends to assign the pain to the digestive guts area, because that is an overwhelmingly complicated part of our body, even by its own standards (heck, it even has its own nervous system).
I don’t know that that is a direct answer now that I’ve written it all out. But hopefully that helps some until someone who knows more comes along.
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