It’s like taking something very delicate, precise and complex, like an expensive clock, and smashing it with a hammer. *Ionizing* radiation by definition has a lot of energy and quite literally punches our molecules so hard they break.
It happens more easily with our molecules than something like a rock because our DNA and cells are extremely complex. There are millions of ways for them to fail, and it only takes a tiny part of them to fail to render the entire molecule useless.
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