I’m not 100% sure about this, but Sertraline, which is the active substance in Zoloft, is an antagonist to numerous receptors, which basically means it has an influence on their function.
One class of receptors, which is partially inhubuted by Sertraline is the alpha-1 adrenergic receptors which is supposed to regulate blood pressure. I suppose that this is the reason for Zoloft causing both insomnia and hypersomnia.
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