If based on natural selection, the other Redditors have answered it.
However if you are asking from a survival POV, my rationale is we (humans) tinker too much.
We have medications and procedures that allows us to prolong/sustain life, promote passing on of genetic diseases and defects.
It’s a slippery slope to start going down so will leave it at that.
I am however GLAD for the tinkering as it has prolong my life but flip side is my kids have a 50/50 chance of having it which will not be known until exposure happens.
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