If your brain gets used to receiving something from outside that it usually makes on its own, it will eventually stop making it. This is called downregulation. This happens because the brain doesn’t want to waste resources making something that’s already there in large amounts.
If the outside supply suddenly stops, the brain won’t have enough of it, leading to problems. The brain then has to re-learn how to make it on its own, which can be a slow and difficult process, especially if you relied heavily on that substance for daily activities.
This adjustment period can cause many problems, such as mood swings, anxiety, changes in appetite, and sleep issues, making it hard to stop craving the substance.
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