All the info needed for a human organism to function is encoded in human DNA and neatly packed in 46 chromosomes. Just like a recipe for a cake – 500g of flour, 4 eggs, 200 g of butter etc etc etc. If you add more information (extra genes in another chromosome), you mess up the recipe – some of your cells will be producing proteins they weren’t meant to produce, some will be confused by the new stuff and won’t do what they need to do etc. Imagine adding 3 more eggs in your cake – it’ll lose structure and you’ll get soup; or adding more flour – you won’t get cake, you’ll get a brick…
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