Is it related to the effect certain drugs have on your body or is there some other reason?
In: Culture
Occams razoring this one: We call being sad “feeling low”. So being happy would be synonymous with feeling “high” or “floating above the clouds” etc. etc.
Drugs make you happy, thus they make you “high”.
Plus, saying “Hey bro wanna go get happy?” doesn’t have the same ring to it.
tl;dr: Its slang.
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