Your guts, the whole several meters of it, is basically separates in two parts: the first is the longer one, the thin one, who’s job is to extract most of the nutrients from the ,what is at that point, mush.
The rectum is the end of the second, significantly shorter, part that has the task of reabsorbing as much water as it can. Water is made of much smaller molecules than nutrients so it’s absorbed, allowed to pass through the wall. Same applies to certain drugs. They are either very similar in size to water or bind to water and carried into the bloodstream along with the water.
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