Other than really wealthy economies with some urban concentrated population (near a sea/ocean), it just gets too expensive. Desalination is energy intensive and water is heavy so moving it around in large volume is also energy intensive.
So while it is technically feasible, it is economically impossible to desalinate water for large scale low value agricultural purposes (for example). The water crisis tends to have a big impact on agricultural populations (low income to begin with so adds less value to the economy) rather than urban centers (higher productivity, wealth and can afford to pay more for water)
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