Not so much as there is no wind, but having the runway face geographical winds can be an advantage and disadvantage. Maybe crosswinds are bad examples of airport runways.
What most architects look for in a site selection would be minimizing disturbances of Noise pollution in neighboring properties, peak hours for land/air traffic congestion, future expansion, accessibility to the public, full security control of the perimeter. That is why many airports are placed on rural area or countrysides.
Distance travel with moving traffic is not so much of a problem compared to a closed distanced airport with a congested traffic which can harm your boarding time.
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