Eli5: how are humans, who are two legged, able to out endure creatures that are four legged?

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Eli5: how are humans, who are two legged, able to out endure creatures that are four legged?

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– Running on two legs is more efficient over long distances than running on four legs
– Humans have the best cooling system of all mammals (sweating), so we don’t overheat as easily as our prey.
– Humans can carry water with them, so they can stay hydrated for longer.

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