eli5: How do painkillers work?

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Like do they make pain in all of the body go away? Or does it just help the bit that’s hurting? Or something else?

In: Biology

3 Answers

Anonymous 0 Comments

Depending on the specific type of painkiller, they target a specific mechanism that the brain uses to detect pain, leading to a general painkiller effect.

Opiates (like morphine) bind to specific receptors in the brain and block pain signals from reaching it.

NSAIDs like aspirin suppress the production of inflammatory signaling molecules, which prevents pain signals from being sent to the brain.

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