The study that originally showed that Ozempic could lead to weight loss showed that people on ozempic ate less than those who weren’t, and people on ozempic lost weight. So the explanation they came to was that ozempic leads to weight loss by causing people to eat less.
There haven’t been any studies on what happens if you force people on ozempic to eat the same amount as people not on ozempic, so nobody really knows what would happen.
But for right now it seems like if you started ozempic but forced yourself to eat the same amount, then you wouldn’t lose weight.
[Source](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573908/)
The appetite suppression side effect from Ozempic probably makes the biggest difference in weight loss, at least at the initial low doses. It makes dieting much easier. Some people don’t even consciously go on a diet, but they still lose weight because they eat less due to suppressed appetite.
At a certain dose, another important effect occurs which seems to lower the body’s resistance to caloric reduction. Diets almost always fail because the body fights against them, and takes metabolic steps to make further weight loss difficult. Ozempic seems to reduce that resistance and allows weight loss to continue for a longer period of time.
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