eli5: why do mouth numbing gels like orajel numb your mouth and teeth but not hands/skin?

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it numbs my tongue instantly but even after 5-10 minutes on skin it feels exactly the same.

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14 Answers

Anonymous 0 Comments

I use oragel for removal of deep slivers. It helps with the pain while you are using a needle to dig the sliver out.

Anonymous 0 Comments

I use oragel for removal of deep slivers. It helps with the pain while you are using a needle to dig the sliver out.

Anonymous 0 Comments

Your mouth (cheeks and gums) are a different type of tissue than skin. It’s much more absorptive and permeable than skin (which is specificlly designed to not absorb stuff you’re touching).

Think about places where hot sauce burns to touch. Eyes, nose lining, mouth/lips, anus, genitals. All of those are mucous membranes, so the spice sinks in. But put some Frank’s Red hot on your palm and it doesn’t feel any different than water – regular skin doesn’t absorb stuff on contact (nearly as much), mucous membranes do.

It’s the same reason you have to snort certain drugs and can’t just rub some of the powder between your hands or on your arm or something. Mucous membranes absorb stuff much more.

Anonymous 0 Comments

Your mouth (cheeks and gums) are a different type of tissue than skin. It’s much more absorptive and permeable than skin (which is specificlly designed to not absorb stuff you’re touching).

Think about places where hot sauce burns to touch. Eyes, nose lining, mouth/lips, anus, genitals. All of those are mucous membranes, so the spice sinks in. But put some Frank’s Red hot on your palm and it doesn’t feel any different than water – regular skin doesn’t absorb stuff on contact (nearly as much), mucous membranes do.

It’s the same reason you have to snort certain drugs and can’t just rub some of the powder between your hands or on your arm or something. Mucous membranes absorb stuff much more.

Anonymous 0 Comments

It actually can be used in the skin, well at least the active ingredient, Benzocaine, can. I just used some a couple of months ago and found out the hard way I’m allergic. My chin is still a bit numb from the experience.

Anonymous 0 Comments

It actually can be used in the skin, well at least the active ingredient, Benzocaine, can. I just used some a couple of months ago and found out the hard way I’m allergic. My chin is still a bit numb from the experience.

Anonymous 0 Comments

Your skin is thicker and chemically different than your mouth. The orajel can easily soak in and actually do the numbing in your mouth, but not nearly as easily on your skin. I wouldn’t recommend it, but you could place it on a papercut, where it can get into that wound and start numbing.

Anonymous 0 Comments

Your skin is thicker and chemically different than your mouth. The orajel can easily soak in and actually do the numbing in your mouth, but not nearly as easily on your skin. I wouldn’t recommend it, but you could place it on a papercut, where it can get into that wound and start numbing.

Anonymous 0 Comments

Skin has an outer layer of deceased keratinized skin cells tightly bound with each other. They’re pretty waterproof and thus also resist absorption of many other things. Including the benzocaine mix in Orajel.

They technically do absorb it, but very very slowly compared to the mucus membrane tissues of the cheeks, tongue, and gums.

Anonymous 0 Comments

Skin has an outer layer of deceased keratinized skin cells tightly bound with each other. They’re pretty waterproof and thus also resist absorption of many other things. Including the benzocaine mix in Orajel.

They technically do absorb it, but very very slowly compared to the mucus membrane tissues of the cheeks, tongue, and gums.