I used to drink to the point of ending up detoxing in hospital (I’m 3 years sober now). I’d be downing vodka but at the same time I’d be downing water too, loads of it. But every time I’d end up in hospital they’d say I was chronically dehydrated. I’d have thick brown pee. I don’t understand it. Where was all the water actually going?!
In: Biology
Your kidneys produces ~100-110 mL of filtrate every **minute**. As a day have 1440 minutes, this means your body produces 144,000 mL or 144 liters of filtrate every day. The only way that it is possible is because the kidney also reabsorbs around 99% of it. And it spends a lot of energy in doing so.
In the distal nephron, there is a segment that is responsible for reabsorbing ~10% of water, called the collecting duct. This segment is sensitive to a hormone called vasopressin or antidiuretic. When this hormone is released, the collecting duct reabsorbs most of the water that pass through it. When this hormone is not released, the collecting duct reabsorbs very little water.
Because the body produces ~144 liters of filtrate every day, it is simple math to understand that if this nephron segment is not working properly, either because the hormone is not produced, or it is produced but the kidney has specific damage to that segment, then it will produce 14 liters of urine per day.
Alcohol directly inhibits the production of that hormone, so while under influence, you are producing ~10mL of diluted urine **per minute**. It is easy to understand that being intoxicated for some hours means producing more pee than a healthy, not intoxicated human, would produce in the entire day.
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