: Over 70% cause of death of patient with Total Artifical Heart died from infection, why?

Question

I get that coagulation and reject is a huge issue, that might lead to stroke and other cardiovascular issue, but over 70% died from lung disease, UTI, or sepsis. How is TAH causing this? Modern antibiotics can’t counter it?

In: Biology

Answer 1

The likely reason for infection is probably because the TAH could have a physical problem such as plastic erosion, this could cause many other problems especially in the lungs and brain.

Another problem could be in the machine, there could be damage or a small opening for microorganisms to have easy access to the bloodstream.