What happens technically when we get exhausted ? is it the oxygen depletion ? or the build up of lactic acid ? why can’t we run/swim/climb forever ?

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I was watching a documentary about high level athletes and it got me thinking about how extraordinary their feats are, can’t we tackle each symptom of exhaustion to make it so that the general public is more capable ? like an oxygen tank for the oxygen need, a cold water container for the thirst and heat and maybe an exoskeleton for an easier time, I’m asking why these notions are not feasible.

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