Pilot here. Moisture and quiet are your friends. Neither are plentiful in planes where the air is dry and the noise is constant. We use noise cancelling headsets and they make a huge difference. Investing in something like the Bose QC35 for consumers can be very smart. Also, drink a bunch of water before you get on the plane, and then drink more throughout the flight. And whatever you do, try to avoid alcohol. It dries you out.
EDIT: Pro tip: bring an empty water bottle with you through security and then fill it up from a water fountain near the gate.
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