I did read somewhere that most commercial planes are only pressurised to mimic a fairly high altitude so if you’re used to living at sea level you might feel more exhausted because you’re not used to the lower-than-usual air pressure. That’s why you can feel particularly zapped after a flight even if you sleep.
A quick Wikipedia search tells me that a 767 is pressurised to 7000 ft which is significantly higher than Denver and SLC and just below Aspen.
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