Why does marijuana seem to increase the efficacy / potency of other drugs?

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This is something I’ve always wondered and I’m sure many people have observed it as well. What about Marijuana causes this, or seems to cause it?

In: Chemistry
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It’s not anything about marijuana per se, but the best answer I can give you is mixing stimuli that act on different neurotransmitters can have compounding effects, like serotonin syndrome, or like the famous DJ screw who died from mixing cocaine, alcohol, and codeine cough syrup.

Marijuana in particular affects your dopamine levels, so combining that with alcohol pronounces the depressant “downer” effects and the naseua. It also throws you “sideways”.

I say there’s “siders”, or disassociatives like DXM, as well as uppers, downers, and hallucinogens.

Marijuana is actually quite hallucinogenic, and when combined with the depressant effects of alcohol I feel a bit “sideways” or disassociated. The street term is “crossfaded”, and it’s actually very harmful for your brain chemistry to do regularly.

Your body is in a heightened state because of dopamine. All senses can be enhanced. Weed is a performance drug.

You should try adding grapefruit to the mix for more fun.

This may not always be the case. Individuals who frequently use marijuana (and redheads for some reason) actually need larger amounts of sedative medication when going into medical procedures.