Just like how a candle burns slower than paper, or how its easier to drink water rather than milk, Different substances have different attributes. A proper chemist might know more, but it kinda makes sense that you could isolate some excesses of a substance that could, in excess, cause problems.
(Calories are a general rule of thumb but any nutritionist knows its more a concern of excessiveness/lack of moderation which causes health problems like weight gain or other more holistic problems like lack of exercise or depression/poor support structure)
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