How does inbreeding in humans cause birth defects?


How does inbreeding in humans cause birth defects?

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Imagine you have a few flavors of ice cream. Now, each time you go get the ice cream, you mix different flavors, creating new flavors with a random chance that that new mix of flavors produces a never before seen flavor (genetic mutations which fuel evolution). Now, imagine you just mix two flavors of same/basically same kind. You’d get the same flavor. The problem arises that in case of mixing same flavors here, you aren’t getting any new flavors, quite the opposite, the flavors gets more and more concentrated, so if your recipe had any issues, those issues are just going to become worse and worse the more of same flavor you add.

Not an expert on the topic as you can tell but this is as simple as id manage to explain what I got from the topic. Basically, you need genetic variety, for DNA and chromosomes to mix because if you have to similar genes, they cant connect properly and you get all kind of issues. I also mentioned that ‘concentration of flavor’ is bad, for example you can look at Hapsburgs chin. Each new generation of Hapsburgs had progressively worse cases of humongous chins which made them famous because of inbreeding.

Everyone has double the genetic information they need and nature favors healthy genes.

Family members tend to have similar bad genes. Inbreeding leads to less probability that the next generation gets good information.

basically any very small issue gets progressively more pronounced with each iteration without external variety. So a small chance of some illness increases to a larger chance with each generation, defects becomes increasing pronounced, some body part get exponential bigger or smaller, mental issues dial another notch with each generation becomes less varied and denser copies of itself.

Tldr;If you are making salad or soup you want variety of ingredients not same one chopped or reduced down together thicker every batch

-Assuming you know what DNA is.

-DNA is a physical molecule, so it can be damaged by chemicals, energy rays, etc. Because of this, the human gene pool has accumulated all sorts of errors over time running in different ethnicities, families, and individuals. Sometimes these errors are bad enough to ruin an entire copy of a gene (protein recipe) and cause it to produce rubbish instead.

-DNA is passed down from parent to child, so there’s a good chance you inherit the same broken copies of genes that your parents have.

-Fortunately, all of us humans have 2 full copies of DNA, one from each parent. Even if one copy of a parent’s gene is ruined, the odds are that we will have a good one to use from the other parent. So there might not be any serious effects from these genetic errors.

-However inbreeding breaks this, because you’re no longer practically guaranteed a “good” copy of any given gene that might have an issue. You’re suddenly put at far higher risk for getting 2 broken copies of these genes, and therefore suffering from their associated health issues. The more genetically related your parents are, the worse the odds.

The more closely related people are, the more their genetic information is similar, including the bad information (mutations) that can be inherited.

Many genetic disorders require 2 bad copies of the gene in order to have the problem (recessive disorder). In a normal family (one that doesn’t marry cousins, or have the same male impregnate several generations of his own female descendants), the chances of having 2 bad pieces of information (mutated genes) at the same spot are slim.

Bleeding easily (hemophilia) is an example of a disease that has been passed by families marrying too closely (like European royalty). The bad genes are the only ones available to pass on.

Mental defects are also very common in inbred populations (any animal).